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Cheapest Place To Buy Amiclear . Verywell Health only uses reliable sources, including peer-reviewed research, to support the facts contained in our articles. The mixture, made up of 24 natural substances, reduces glucose levels in the blood without requiring synthetic drugs. Anju Soomd, Nutritionist, claims that Karela juice can make your insulin active. These symptoms can be mild or severe, so it's important that you have regular screenings to determine if your diabetes is a concern.